Remantadine: Side Effects and Contraindications

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Antiviral agent of the first generation. Excellent proven to fight flu. Helps prevent infection and development of severe forms of the disease. Allowed to receive adults and children.


What is remantadin

Drug Treatment based on Rimantadine hydrochloride, Adamantan derivative. This substance blocks the reproduction of some groups of influenza viruses and encephalitis at an early stage of infection, due to which the development of diseases stops.

Remantadine is produced in the form of tablets in a dosage of 50 mg and 100 mg capsules. The pill also includes auxiliary components: talc, starch, calcium stearate, lactose.

For the treatment of children, anti-virus syrups are produced with a rimantadine content on the matrix carrier - Alginim and Orvim.

Mechanism of action

Remantadine prevents the transmission of RNA viruses to the cytoplasm, its particles surround pathogens and blocks the fusion of their shells with cell membranes. The drug is effective against influenza and encephalitis influenza. It is capable of preventing the reproduction of infection during primary contacts with viruses, weakens the symptoms of a developed disease and shortens its flow. Therapeutic effect is most pronounced with the use of funds in the first 10-15 hours after infection.

It has been established that the drug has a moderate antitoxic effect during ARVI, facilitates fever, improves the well-being of the influenza with influenza.

From the cavity of the stomach remantine is absorbed slowly. Most of the substance concentrates in nasal mucus. The plasma contains its content - less than 50%. Transformation in the liver. Metabolites are filtered and removed by the kidneys within 1-1.5 days after the reception. With a reduced function of the urinary system, this period is doubled.

Instruction: From what age when and how much to accept remant

The drug can be used as prophylaxis:

  • during seasonal ORVI and influenza epidemics;

  • after contact with infected and sick;

  • To prevent tick-borne encephalitis when its possible carriers are detected on the body.

The prevention of influenza requires reception of the tablets within 10-30 days: 1 pcs. in a day. When tick bite, it is important to drink medicine in the first 3 days: 2 tabs. twice a day.

With SMI symptoms on the first day, remantadine drink 2 tab. Three times a day, in the next 2 days - reduce the dose on ⅓, on the fourth day take 2 tabs.

Children from 1 year prescribe syrups with Rimantadin:

  • Babies up to 3 years old: 20 mg (2 hours) three times a day for 4 days, reducing the dose daily on ⅓;

  • Children 3-7 years old: 3 h. Three times a day, similarly reducing the dose every day.

Tablets are allowed for use for children from 7 years: 1 pcs. Three times a day for 4-5 days in the treatment of influenza. For prevention, the drug is drinking 1 tab. Not more than 1 time per day. Course - up to 15 days.

The medicine is consumed after 1-1.5 hours. After meals, they are driving with a large volume of water.

Can remantadine be taken during pregnancy and lactation

The antiviral substance penetrates through the placental barrier and can disrupt the normal development of the fetus. Pregnant women need to choose to treat other groups of drugs. In the period of breastfeeding, it is also undesirable to apply it undesirable due to the high risk of allergic reactions in a child. With the infection of infection and the need for the prevention of remant diabetes, it is recommended to temporarily change the type of child's nutrition, going to the adapted mixtures or reserves of the milk.

Side effects

In some cases, against the background of the drug is likely:

  • DISPERSIONS: Impairment of appetite, dry mouth, nausea, stomach pain;

  • violation of the concentration of attention, increased drowsiness, anxiety;

  • headaches.

In case of overdose, negative reactions of the body are enhanced. Acute intoxication leads to the appearance of metal lifting, indomitable vomiting, confusion of consciousness, rinic attacks, hallucinations. In such cases, urgent rinsing of the stomach and drug detoxification are required.


Refuse to receive remantadadine follows:

  • Children up to 1 year;

  • with renal or liver failure;

  • heavy forms of hypertension;

  • with epilepsy;

  • thyrotoxicosis;

  • individual intolerance;

  • At all periods of pregnancy and in the GW.

With caution, the drug needs to be taken with atherosclerosis and with violations of cerebral circulation. Remantadine increases the risk of hemorrhagic stroke.

Interaction with other drugs

Means, enveloping mucous gasts slow down the absorption of the active component of remant palp. With simultaneous reception of enterosorbents, the same effect is observed. In addition, the antiviral action decreases when combining with medicines that score urine.

The concentration of the drug in the blood becomes lower with the simultaneous use of aspirin and paracetamol. Remantadine reduces the effectiveness of antiepileptic therapy.

What is better: Remantadine, Arbidol or Kagocell

Due to the constant mutation of influenza viruses, remantadin may be powerless before the next infection. For these reasons, it is relevant not only to use antiviral therapy, but also immunomodulators - means that increase the specific protection of the organism from certain pathogens.

Arbidol and Kagocele are not analogues of remantaddine, although they are also used for the prevention and treatment of influenza at an early stage. These drugs stimulate the production of their own interferons that destroy the infection. They are effective in relation to several groups of pathogens. The feasibility of the appointment of this or that medicine can only determine the attending physician after the examination.



Indications for use

Influenza A (early treatment in adults and prevention in children and adults).

Possible analogs (substitutes)

Active ingredient, group

Dosage form

Syrup [for children], tablets, pills covered with shell


Hypersensitivity, pregnancy, lactation, children's age (up to 1 year).

C care. Epilepsy (including history), severe CPN, liver failure.

How to apply: dosage and treatment course

Inside, after eating, drinking water.

Prevention: inside, adults and children over 10 years 100 mg 2 times a day, children under 10 years old - 5 mg / kg 1 time per day. The maximum daily dose for children should not exceed 150 mg.

Treatment: 100 mg 2 times a day for 5-7 days after the appearance of symptoms of the disease.

For the treatment and prevention of influenza with CPN (QC less than 10 ml / min), heavy liver failure, elderly patients in nursing homes - 100 mg 1 time per day.

The treatment of influenza and should be started for 24-48 hours after the appearance of symptoms of the disease and continue within 5-7 days. The optimal duration is not installed.

pharmachologic effect

Antiviral agent, derivative of Adamantan; Effectively with respect to different strains of influenza a virus, Herpes Simplex types I and II viruses, tick-borne encephalitis viruses (Central European and Russian Spring-Summer Group of Arbovirus Group Flaviviridae). It has antitoxic and immunomodulatory effect.

The polymer structure provides long-term circulation in the body, which allows it to be applied not only with therapeutic, but also with a preventive purpose. Suppresses the early stage of specific reproduction (after the penetration of the virus in the cell and to the initial transcription of RNA); Induces the production of interferon alpha and gamma, increases the functional activity of lymphocytes - natural killers (NK cells), T- and B-lymphocytes.

As a weak basis, increases the pH endos, having a vacuole membrane and surrounding viral particles after their penetration into the cell. Preventing acidification in these vacuoles blocks the fusion of the viral shell with the membrane of the endosome, preventing T.O. Transfer of viral genetic material to cytoplasm cells. The drug also oppresses the yield of virus particles from the cell, i.e. Interrupts the transcription of the viral genome.

Preventive purpose in a daily dose of 200 mg reduces the risk of influenza disease, as well as reduces the severity of flu symptoms and serological reaction. Some therapeutic effect may also appear when it is appointed in the first 18 hours after the development of the first symptoms of influenza.

Side effects

From the CNS: Reducing the ability to concentrate attention, insomnia, dizziness, headache, nervousness, excessive fatigue.

From the digestive system: dry mouth, anorexia, nausea, gastralgy, vomiting.

special instructions

Compared with amantadine has higher clinical efficacy and less toxic.

The appearance of resistant viruses is possible.

With a flu caused by a virus in, has an antitoxic effect.

Preventive reception is effective when contacting with sick (taking the drug is necessary at least within 10 days after contact), when the infection is spreading in closed groups and at a high risk of the disease during the flu epidemic. During the epidemic, it should be prescribed daily, usually within 6-8 weeks or to the expected development of active immunity after the immunization of the inactivated flu vaccine A. while simultaneously appointing with an inactivated flu vaccine A to the appearance of protective antibodies should be prescribed prophylactically within 2-3 weeks After the introduction of the vaccine (since the effectiveness of the vaccine is only 70-80%, in elderly patients or high risk, more prolonged use). If the vaccine is not available or immunization is contraindicated, it should be prescribed in cases of possible re-or accidental infection for up to 90 days.

The drug is effective for influenza prevention after contact with a sick family member, but is less effective in preventive use in a family in which the influenza and the influenza A were obtained in preventive purposes (probably due to the transfer of viruses resistant to the drug).

During the period of treatment, care must be taken when driving vehicles and the class of other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Application during pregnancy and lactation

Contraindicated during pregnancy and lactation.


Paracetamol and ASC reduce Cmax by 11 and 10%, respectively.

Cimetidine reduces the clearance of the drug by 18%.

Storage conditions

In the dry place protected from light, at a temperature not higher than 25 ° C.

Keep out of the reach of children.

Shelf life

5 years.

After the expiration date, the drug does not apply.

Questions, Answers, Reviews on the drug Rimantadin


Hello, is it possible to drink Rimantadin for prophylaxis from laryngitis?

Hello. The drug Rimantadine is used for the treatment and prevention of influenza A.


Good afternoon, please tell me, and you can take antideprissant and Rimantadine simultaneously

Hello. Please specify the question. What a specific antidepressant you are taking.


Can it be simultaneously taken


And Rimantadin


By appointing the attending physician - you can.


Hello, 5days saw an antiviral drug Rimantadine, the next day she drank 1st


and calcium drank


. Forces and stains partially passed. Is it possible to simultaneously take zetrin and suprastin in injections? Thanks.


Apparently, the allergic reaction caused a tincture, it is not necessary to take it anymore. No injections without personal doctor do not do. In addition, at the same time, prick Supratin and taking a zetrin inside is irrational, they have a similar action. Based on your description, there should be enough zetrin.



Child 9 years old. Feldsher in the village appointed


Rimantadin. Is it possible to take them together. In the temperature

39 And the throat inflamed.


* Yes, in this case, these drugs can be taken together.

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